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Chemistry, Biochemistry, and Chemical & Biological Engineering Reference Guide: Reactions and Synthesis

This Guide contains Chemistry and Chemical & Biological Engineering resources and information. Links below provide a starting place for your research project.

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Vincent Scalfani
Science and Engineering Librarian

109 Rodgers Library


Reactions and Synthesis



Use explore reactions to search by structure. If you can not find what you are looking for, try an Explore References search with a natural language phrase of what you are trying to locate. For example, “synthesis of X” or “deprotection of TIPSO”.

‚ÄčOrganic Syntheses

Published reproducible organic syntheses methods. Each method is checked before publication. Search by keyword or structure (requires a ChemDraw Plugin)

Inorganic Syntheses

Published reproducible inorganic syntheses methods. Each method is checked before publication.

ChemSpider React

Search by keyword, author name, product, and structure.

Reviews and Self Study

Advanced Organic Chemistry Part A: Structure and Mechanisms

Great organic chemistry text with many references to primary literature. This is a very readable reference book (Both Part A and B) if you already have some knowledge of organic chemistry.

Advanced Organic Chemistry Part B: Reactions and Synthesis

Provides a great discussion of important organic reactions including descriptions of mechanisms, stereochemistry, and reaction conditions. Part B also includes many references to the primary literature.

March’s Advanced Organic Chemistry

Another excellent organic chemistry text with a focus on reactions, mechanisms, and structure. Includes many references to primary literature including checked reactions from Organic Syntheses. N.B. contains a section in Appendix A about Literature resources in organic chemistry.

The Art of Writing Reasonable Organic Reaction Mechanisms

Teach yourself how to write reaction mechanisms.

Other Selected Reference Books

ACS Reagent Chemicals Online

Provides general physical properties and analytical uses for reagent chemicals as well as guidelines for standard analytical methods. Purity specifications for reagent chemicals and standard-grade reference materials.

The Manipulation of Air-Sensitive Compounds

Key resource for safely handling chemicals under inert atmosphere. 

Comprehensive Organic Functional Group Transformations

Comprehensive Organic Functional Group Transformations II

Both of these text are arranged by number of attached non-carbon atoms. Version II is available online through Knovel.

Comprehensive Organic Transformations: A Guide to Functional Group Preparations

Arranged by bond order/functional group and then transformation. I find this text easy to browse.

Greene’s Protective Groups in Organic Synthesis

Organized by group to be protected including deprotection conditions.

Strategic Applications of Named Reactions in Organic Synthesis

Named reactions in organic synthesis with reaction mechanisms and references to primary literature.